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Article

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy.

The pharmacogenomics journal - 1 Jan 2001

Pullarkat S T, Stoehlmacher J, Ghaderi V, Xiong Y P, Ingles S A, Sherrod A, Warren R, Tsao-Wei D, Groshen S, Lenz H J

Abstract excerpt

Thymidylate synthase (TS) catalyses the conversion of deoxy-uridylate to deoxy-thymidylate and is essential for DNA synthesis. The human TS gene promoter is polymorphic, having either double or triple tandem repeats of a 28-bp sequence. Here we determined the significance of this polymorphism in humans and its prediction for clinical outcome of patients with metastatic colorectal cancer treated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11913730
DOI: 10.1038/sj.tpj.6500012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy.PMID 11913730Read ↗

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