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Expression quantitative trait loci in ABC transporters are associated with survival in 5-FU treated colorectal cancer patients.

Mutagenesis - 11 Jul 2020

Vymetalkova Veronika, Rosa Fabio, Susova Simona, Bendova Petra, Levy Miroslav, Buchler Tomas, Kral Jan, Bartu Linda, Vodickova Ludmila, Hughes David J, Soucek Pavel, Naccarati Alessio, Kumar Rajiv, Vodicka Pavel, Pardini Barbara

Abstract excerpt

The chemotherapeutic efficacy in colorectal cancer (CRC) is limited due to the inter-individual variability in drug response and the development of tumour resistance. ATP-binding cassette (ABC) transporters are crucial in the development of resistance by the efflux of anticancer agents from cancer cells. In this study, we identified 14 single nucleotide polymorphisms (SNPs) in 11 ABC transporter genes acting as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31922572
DOI: 10.1093/mutage/gez050

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