Article
Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.
Cell cycle (Georgetown, Tex.) - 1 Apr 2008
Bisson Nicolas, Tremblay Michel, Robinson Fiona, Kaplan David R, Trusko Steven P, Moss Tom
Abstract excerpt
The mitogen-activated protein kinase kinase kinases of the mixed-lineage kinase (MLK) family have been shown to activate the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathway, and to regulate the other two principal MAPK cascades, p38 and extracellular signal-regulated kinase (ERK). Although there is growing evidence for their involvement in neuronal cell death leading to...
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