Article
K-ras is an essential gene in the mouse with partial functional overlap with N-ras.
Genes & development - 1 Oct 1997
Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson R T, Umanoff H, Edelmann W, Kucherlapati R, Jacks T
Abstract excerpt
Mammalian ras genes are thought to be critical in the regulation of cellular proliferation and differentiation and are mutated in approximately 30% of all human tumors. However, N-ras and H-ras are nonessential for mouse development. To characterize the normal role of K-ras in growth and development, we have mutated it by gene targeting in the mouse. On an inbred genetic background, embryos homozygous for this...
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