Article
K-ras is an essential gene in the mouse with partial functional overlap with N-ras.
Genes & development - 1 Oct 1997
Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson R T, Umanoff H, Edelmann W, Kucherlapati R, Jacks T
Abstract excerpt
Mammalian ras genes are thought to be critical in the regulation of cellular proliferation and differentiation and are mutated in approximately 30% of all human tumors. However, N-ras and H-ras are nonessential for mouse development. To characterize the normal role of K-ras in growth and developm...
Topics
- Anemia
- Animals
- Cells, Cultured
- Chimera
- Embryonic and Fetal Development
- Female
- Gene Expression Regulation, Developmental
- Gene Targeting
- Genes, ras
- Hematopoiesis
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Neoplasms