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Article

Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.

PloS one - 3 May 2011

Warr Nick, Bogani Debora, Siggers Pam, Brixey Rachel, Tateossian Hilda, Dopplapudi Asha, Wells Sara, Cheeseman Michael, Xia Ying, Ostrer Harry, Greenfield Andy

Abstract excerpt

In mammals, the Y chromosome is a dominant male determinant, causing the bipotential gonad to develop as a testis. Recently, cases of familial and spontaneous 46,XY disorders of sex development (DSD) have been attributed to mutations in the human gene encoding mitogen-activated protein kinase kinase kinase 1, MAP3K1, a component of the mitogen-activated protein kinase (MAPK) signal transduction pathway. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21559298
DOI: 10.1371/journal.pone.0019572
PMCID: PMC3086927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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