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Article

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.

PloS one - 1 Jan 2014

Reiling Erwin, Dollé Martijn E T, Youssef Sameh A, Lee Moonsook, Nagarajah Bhawani, Roodbergen Marianne, de With Piet, de Bruin Alain, Hoeijmakers Jan H, Vijg Jan, van Steeg Harry, Hasty Paul

Abstract excerpt

Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80-/- mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pkcs-/- mice. However, these observations are based on independent studies with varying genetic backgrounds. Here, we generated ku80-/-, dna-pkcs-/- and double knock out mice in a...

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Identifiers

PMID: 24740260
DOI: 10.1371/journal.pone.0093568
PMCID: PMC3989187

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