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Article

Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.

Molecular and cellular biology - 1 Nov 2007

Wang Xin, Nadarajah Bagirathy, Robinson Andrew C, McColl Barry W, Jin Jia-Wei, Dajas-Bailador Federico, Boot-Handford Raymond P, Tournier Cathy

Abstract excerpt

The c-Jun NH2-terminal protein kinase (JNK) is a mitogen-activated protein kinase (MAPK) involved in the regulation of various physiological processes. Its activity is increased upon phosphorylation by the MAPK kinases MKK4 and MKK7. The early embryonic death of mice lacking an mkk4 or mkk7 gene has provided genetic evidence that MKK4 and MKK7 have nonredundant functions in vivo. To elucidate the physiological...

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Identifiers

PMID: 17875933
DOI: 10.1128/MCB.00226-07
PMCID: PMC2169138

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