Article
Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations.
Cell - 28 Jun 1991
Schwartzberg P L, Stall A M, Hardin J D, Bowdish K S, Humaran T, Boast S, Harbison M L, Robertson E J, Goff S P
Abstract excerpt
The c-abl gene, originally identified as the cellular homolog of the transforming gene of the Abelson murine leukemia virus, encodes a protein-tyrosine kinase of unknown function that is expressed in all mammalian tissues. We have previously described the introduction of a mutation in the c-abl gene into the mouse germline via targeted gene disruption of embryonic stem cells. We now show that mice homozygous for...
Topics
- Animals
- Antigens, Differentiation, B-Lymphocyte
- Antigens, Differentiation, T-Lymphocyte
- B-Lymphocyte Subsets
- Bone Marrow Cells
- Bone Marrow Transplantation
- Eye Abnormalities
- Flow Cytometry
- Hematopoiesis
- Homozygote