Article
Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations.
Cell - 28 Jun 1991
Schwartzberg P L, Stall A M, Hardin J D, Bowdish K S, Humaran T, Boast S, Harbison M L, Robertson E J, Goff S P
Abstract excerpt
The c-abl gene, originally identified as the cellular homolog of the transforming gene of the Abelson murine leukemia virus, encodes a protein-tyrosine kinase of unknown function that is expressed in all mammalian tissues. We have previously described the introduction of a mutation in the c-abl gene into the mouse germline via targeted gene disruption of embryonic stem cells. We now show that mice homozygous for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.