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Article

Disruption of MKK4 signaling reveals its tumor-suppressor role in embryonic stem cells.

Oncogene - 10 Jun 2004

Cazillis Michèle, Bringuier Annie-France, Delautier Danièle, Buisine Maud, Bernuau Dominique, Gespach Christian, Groyer André

Abstract excerpt

The dual Ser/Thr kinase MKK4 and its downstream targets JNK and p38 regulate critical cellular functions during embryogenesis and development. MKK4 has been identified as a putative tumor-suppressor gene in human solid tumors of breast, prostate and pancreas. To clarify the mechanisms underlying the transforming potential of molecular defects targeting MKK4, we have generated totipotent embryonic stem (ES) cells...

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Identifiers

PMID: 15122334
DOI: 10.1038/sj.onc.1207619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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