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Article

Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.

Journal of cell science - 1 Jul 2011

Yokoyama Akihiko, Ficara Francesca, Murphy Mark J, Meisel Christian, Naresh Alpana, Kitabayashi Issay, Cleary Michael L

Abstract excerpt

The mixed lineage leukemia (MLL) proto-oncogenic protein is a histone-lysine N-methyltransferase that is produced by proteolytic cleavage and self-association of the respective functionally distinct subunits (MLL(N) and MLL(C)) to form a holocomplex involved in epigenetic transcriptional regulation. On the basis of studies in Drosophila it has been suggested that the separated subunits might also have distinct...

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Share to Histone-Lysine N-Methyltransferase
Share to Leukemia, T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid-Lymphoid Leukemia Protein

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Share to Protein Processing, Post-Translational

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Identifiers

PMID: 21670200
DOI: 10.1242/jcs.080523
PMCID: PMC3113671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.PMID 21670200Read ↗

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