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Article

Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.

EMBO reports - 1 Aug 2002

Tanaka Nobuyuki, Kamanaka Masahito, Enslen Hervé, Dong Chen, Wysk Mark, Davis Roger J, Flavell Richard A

Abstract excerpt

The p38 mitogen-activated protein kinase (p38MAPK) is activated in response to various stimuli, including cellular stress, inflammatory cytokines and cell surface receptors. The activation of p38MAPK is predominantly mediated by the two upstream MAPK kinases MKK3 and MKK6. To study the role of the p38MAPK pathway in vivo, we generated Mkk6-/- mice. We examined whether T-cell apoptosis is affected in these mice...

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Identifiers

PMID: 12151339
DOI: 10.1093/embo-reports/kvf153
PMCID: PMC1084207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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