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Article

Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.

Molecular and cellular biology - 1 Aug 2002

Guo Zijian, Clydesdale Gavin, Cheng Jinke, Kim Kihwan, Gan Lin, McConkey David J, Ullrich Stephen E, Zhuang Yuan, Su Bing

Abstract excerpt

MEKK2 is a member of the mitogen-activated protein kinase (MAPK) kinase kinase gene family involved in regulating multiple MAPK signaling pathways. To elucidate the in vivo function of MEKK2, we generated mice carrying a targeted mutation in the Mekk2 locus. Mekk2(-/-) mice are viable and fertile. Major subsets of thymic and spleen T cells in Mekk2-deficient mice were indistinguishable from those in wild-type...

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Identifiers

PMID: 12138187
DOI: 10.1128/MCB.22.16.5761-5768.2002
PMCID: PMC133978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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