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Article

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

Molecular and cellular biology - 1 Nov 2003

Shi Yu, Kotlyarov Alexey, Laabeta Kathrin, Gruber Achim D, Butt Elke, Marcus Katrin, Meyer Helmut E, Friedrich Anke, Volk Hans-Dieter, Gaestel Matthias

Abstract excerpt

MK5 (mitogen-activated protein kinase [MAPK]-activated protein kinase 5), also designated PRAK (p38-regulated and -activated kinase), was deleted from mice by homologous recombination. Although no MK5 full-length protein and kinase activity was detected in the MK5 knockout mice, the animals were viable and fertile and did not display abnormalities in tissue morphology or behavior. In addition, these mice did not...

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Identifiers

PMID: 14560018
DOI: 10.1128/MCB.23.21.7732-7741.2003
PMCID: PMC207624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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