Article
Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.
Biochemistry - 28 Dec 2004
Durkin John T, Holskin Beverly P, Kopec Karla K, Reed Matt S, Spais Chrysanthe M, Steffy Brian M, Gessner George, Angeles Thelma S, Pohl Jan, Ator Mark A, Meyer Sheryl L
Abstract excerpt
Mixed-lineage kinase 1 (MLK1) is a mitogen-activated protein kinase kinase kinase capable of activating the c-Jun NH(2)-terminal kinase (JNK) pathway. Full-length MLK1 has 1104 amino acids and a domain structure identical to MLK2 and MLK3. Immunoblot and mass spectrometry show that MLK1 is threonine (and possibly serine) phosphorylated in or near the activation loop. A kinase-dead mutant is not, consistent with...
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