Article
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Nature genetics - 1 May 2008
Haigis Kevin M, Kendall Krystle R, Wang Yufang, Cheung Ann, Haigis Marcia C, Glickman Jonathan N, Niwa-Kawakita Michiko, Sweet-Cordero Alejandro, Sebolt-Leopold Judith, Shannon Kevin M, Settleman Jeffrey, Giovannini Marco, Jacks Tyler
Abstract excerpt
Kras is commonly mutated in colon cancers, but mutations in Nras are rare. We have used genetically engineered mice to determine whether and how these related oncogenes regulate homeostasis and tumorigenesis in the colon. Expression of K-Ras(G12D) in the colonic epithelium stimulated hyperproliferation in a Mek-dependent manner. N-Ras(G12D) did not alter the growth properties of the epithelium, but was able to...
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