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Article

Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants.

Cells - 3 Dec 2019

Alcantara Krizelle Mae M, Malapit Joshua Reginald P, Yu Ryan Timothy D, Garrido Jose Antonio Ma G, Rigor John Paul T, Angeles Arlou Kristina J, Cutiongco-de la Paz Eva Maria, Garcia Reynaldo L

Abstract excerpt

RAS oncogene family members are molecular switches of signaling pathways that control cell growth, proliferation, differentiation, and survival. In colorectal cancer, Kirsten-RAS (KRAS) and neuroblastoma-RAS (NRAS) are the commonly mutated isoforms. Activating mutations in RAS result in cellular transformation independent of upregulated epidermal growth factor receptor (EGFR)-initiated signaling. The present...

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PMID: 31816869
DOI: 10.3390/cells8121557
PMCID: PMC6952822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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