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Article

Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.

Cancer cell - 9 Aug 2010

Bennecke Moritz, Kriegl Lydia, Bajbouj Monther, Retzlaff Kristin, Robine Sylvie, Jung Andreas, Arkan Melek C, Kirchner Thomas, Greten Florian R

Abstract excerpt

Colonic cancers with a serrated morphology have been proposed to comprise a molecularly distinct tumor entity following an alternative pathway of genetic alterations independently of APC mutations. We demonstrate that intestinal epithelial cell specific expression of oncogenic K-ras(G12D) in mice...

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Source

Identifiers

PMID: 20708155
DOI: 10.1016/j.ccr.2010.06.013

Genes

APC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20708155-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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