Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.

doi:10.1111/iep.12064

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.

International journal of experimental pathology - 1 Feb 2014

Luo Feijun, Poulogiannis George, Ye Hongtao, Hamoudi Rifat, Dong Gehong, Zhang Wenyan, Ibrahim Ashraf E K, Arends Mark J

Abstract excerpt

K-ras mutations are found in ~40% of human colorectal adenomas and carcinomas and contribute to colorectal tumour formation at an early stage. Wild-type K-ras has been reported to be deleted in some tumours, but the consequences of changes in wild-type K-ras copy number for experimental colorectal carcinogenesis have not been investigated. To characterize the effects of K-ras copy number changes on formation of...

Topics

1,2-Dimethylhydrazine
Adenoma
Alleles
Animals
Apoptosis
Cell Proliferation
Colorectal Neoplasms
Disease Models, Animal
Female
Gene Dosage
Hemizygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Knockout

Proto-Oncogene Proteins p21(ras)

Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24354449
DOI: 10.1111/iep.12064
PMCID: PMC3919644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24354449-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.PMID 24354449Read ↗

Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.Semantic proximity Read ↗

K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.Semantic proximity Read ↗

Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.Semantic proximity Read ↗

<i>KRAS</i> allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer <i>in vivo</i>Semantic proximity Read ↗

Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?Semantic proximity Read ↗

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.Semantic proximity Read ↗

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.Semantic proximity Read ↗

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.Semantic proximity Read ↗

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.Semantic proximity Read ↗

Mouse models of colorectal cancerSemantic proximity Read ↗

Mouse models for the discovery of colorectal cancer driver genes.Semantic proximity Read ↗

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.