Article
K-Ras, intestinal homeostasis and colon cancer.
Current clinical pharmacology - 1 Jan 2015
Goel Sanjay, Huang Jie, Klampfer Lidija
Abstract excerpt
Activating Ras mutations, present in about 20% of human cancers, compromise the GTPase activity of Ras and therefore trigger accumulation of Ras in the GTP-bound state. Among the three family members, K-Ras, H-Ras and N-Ras, K-Ras is the most frequently mutated gene, with 30-50% of colon cancer p...
Topics
- Animals
- Antineoplastic Agents
- Cell Proliferation
- Cell Survival
- Colonic Neoplasms
- Disease Progression
- ErbB Receptors
- Genes, ras
- Homeostasis
- Humans
- Mutation
- Prognosis
- Signal Transduction