Article
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 19 Sept 2006
Sansom Owen J, Meniel Valerie, Wilkins Julie A, Cole Alicia M, Oien Karin A, Marsh Victoria, Jamieson Thomas J, Guerra Carmen, Ashton Gabrielle H, Barbacid Mariano, Clarke Alan R
Abstract excerpt
Oncogenic mutations in the K-ras gene occur in approximately 50% of human colorectal cancers. However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To address this issue, we have conditionally expressed an oncogenic K-ras(V12) allele in the small intestine of adult mice either alone or in the context of Apc deficiency. We found that expression of K-ras(V12) does not affect...
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