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Article

Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool.

Gastroenterology - 1 Sept 2011

Feng Ying, Bommer Guido T, Zhao Jenny, Green Maranne, Sands Evan, Zhai Yali, Brown Kelly, Burberry Aaron, Cho Kathleen R, Fearon Eric R

Abstract excerpt

BACKGROUND & AIMS: Adenomatous polyps are precursors to colorectal cancer (CRC), whereas hyperplastic polyps (HPPs) have low risk of progression to CRC. Mutations in KRAS are found in ∼40% of CRCs and large adenomas and a subset of HPPs. We investigated the reasons why HPPs with KRAS mutations lack malignant potential and compared the effects of Kras/KRAS activation with those of Apc/APC inactivation, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21699772
DOI: 10.1053/j.gastro.2011.05.007
PMCID: PMC3163826

Genes

KRAS
APC
HES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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