Article
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
The Journal of pathology - 1 Feb 2011
Luo Feijun, Poulogiannis George, Ye Hongtao, Hamoudi Rifat, Zhang Wenyan, Dong Gehong, Arends Mark J
Abstract excerpt
K-ras (KRAS) mutations are observed in around 40% of human colorectal adenomas and carcinomas. Previously, we developed and characterized a strain of transgenic mice with inducible intestinal epithelial expression of K-ras{Val12} via a Cre/LoxP system. To evaluate the influence of mutant K-ras on...
Topics
- 1,2-Dimethylhydrazine
- Adenoma
- Animals
- Apoptosis
- Carcinogens
- Cell Proliferation
- Cell Transformation, Neoplastic
- Chromosomal Instability
- Cluster Analysis
- Colorectal Neoplasms
- Disease Models, Animal
- Gene Expression Profiling
- Genes, ras
- MAP Kinase Signaling System
- Mice
- Mice, Transgenic
- Mutation
- Neoplasm Proteins