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Article

The impact of K-Ras Gly12 mutants on homeostasis and tumorigenesis in the colonic epithelium.

Oncogene - 1 May 2026

Yang Moon Hee, Sheth Shikha, Shui Bing, Grabski Isabella N, Park Samuel Seongmin, Cobo Ana, Irizarri Rafael, Heymach John V, Dow Lukas E, Haigis Kevin M

Abstract excerpt

K-Ras represents one of the most frequently mutated and therapeutically relevant oncogenic drivers. Clinical and epidemiological data suggest association between specific KRAS alleles, therapeutic responses, and patient outcomes, however, direct experimental validation of these relationships has been limited. In this study, we investigate the differential impacts of three most common K-Ras G12 mutants (K-RasG12C,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins p21(ras)

Source

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Identifiers

PMID: 41963618
DOI: 10.1038/s41388-026-03771-3
PMCID: PMC13139037

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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