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Article

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.

International journal of cancer - 1 Jun 2008

Calcagno Shelly R, Li Shuhua, Colon Migdalisel, Kreinest Pamela A, Thompson E Aubrey, Fields Alan P, Murray Nicole R

Abstract excerpt

Oncogenic K-ras mutations are frequently observed in colon cancers and contribute to transformed growth. Oncogenic K-ras is detected in aberrant crypt foci (ACF), precancerous colonic lesions, demonstrating that acquisition of a K-ras mutation is an early event in colon carcinogenesis. Here, we investigate the role of oncogenic K-ras in neoplastic initiation and progression. Transgenic mice in which an oncogenic...

Topics

Animals
Azoxymethane
Carcinogens
Colonic Neoplasms
Gene Expression Regulation, Neoplastic
Genes, ras
Immunoblotting
Immunohistochemistry
Intestinal Mucosa
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mutation

Precancerous Conditions

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 18271008
DOI: 10.1002/ijc.23383
PMCID: PMC3908548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18271008-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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