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Article

Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2018

Rice Photini F S, Ehrichs Kevin G, Jones Mykella S, Chen Hwudarw, Hsu Chiu-Hsieh, Abril Edward R, Nagle Raymond B, Besselsen David G, Barton Jennifer K, Ignatenko Natalia A

Abstract excerpt

The NSAID sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition and also showed its efficacy in prevention of sporadic colon adenomas. At the same time, some experimental and clinical reports suggest that a mutant K-RAS oncogene may negate sulindac antitumor efficacy. To directly assess sulindac activity at suppressing...

Topics

Animals
Antineoplastic Agents
Azoxymethane
Carcinogens
Cell Transformation, Neoplastic
Colonic Neoplasms
Mice
Mice, Inbred C57BL
Mutation
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sulindac

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Identifiers

PMID: 29118162
DOI: 10.1158/1940-6207.CAPR-17-0230
PMCID: PMC7733710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29118162-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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