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Article

Anionic phospholipids affect the rate and extent of flux through the mechanosensitive channel of large conductance MscL.

Biochemistry - 8 Apr 2008

Powl Andrew M, East J Malcolm, Lee Anthony G

Abstract excerpt

The mechanosensitive channel of large conductance MscL from Escherichia coli has been reconstituted into sealed vesicles, and the effects of lipid structure on the flux of the fluorescent molecule calcein through the open channel have been studied. The channel was opened by reaction of the G22C mutant of MscL with the reagent [2-(triethylammonium)ethyl]methanethiosulfonate (MTSET) which introduces five positive...

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Identifiers

PMID: 18341289
DOI: 10.1021/bi702409t
PMCID: PMC2566799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Anionic phospholipids affect the rate and extent of flux through the mechanosensitive channel of large conductance MscL.PMID 18341289Read ↗

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