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Article

Dynamics of protein-protein interactions at the MscL periplasmic-lipid interface.

Biophysical journal - 21 Jan 2014

Zhong Dalian, Yang Li-Min, Blount Paul

Abstract excerpt

MscL, the highly conserved bacterial mechanosensitive channel of large conductance, is one of the best studied mechanosensors. It is a homopentameric channel that serves as a biological emergency release valve that prevents cell lysis from acute osmotic stress. We previously showed that the periplasmic region of the protein, particularly a single residue located at the TM1/periplasmic loop interface, F47 of...

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Identifiers

PMID: 24461012
DOI: 10.1016/j.bpj.2013.12.006
PMCID: PMC3907235

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