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Article

Cysteine scanning of MscL transmembrane domains reveals residues critical for mechanosensitive channel gating.

Biophysical journal - 1 May 2004

Levin Gal, Blount Paul

Abstract excerpt

The mechanosensitive channel of large conductance (MscL), a bacterial channel, is perhaps the best characterized mechanosensitive protein. A structure of the Mycobacterium tuberculosis ortholog has been solved by x-ray crystallography, but details of how the channel gates remain obscure. Here, cysteine scanning was used to identify residues within the transmembrane domains of Escherichia coli MscL that are...

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Identifiers

PMID: 15111403
DOI: 10.1016/S0006-3495(04)74338-6
PMCID: PMC1304155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cysteine scanning of MscL transmembrane domains reveals residues critical for mechanosensitive channel gating.PMID 15111403Read ↗

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