Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mechanosensitive channel of small conductance (MscS) functions as a Jack-in-the box.

Biochimica et biophysica acta - 1 Jan 2015

Malcolm Hannah R, Blount Paul, Maurer Joshua A

Abstract excerpt

Phenotypical analysis of the lipid interacting residues in the closed state of the mechanosensitive channel of small conductance (MscS) from Escherichia coli (E. coli) has previously shown that these residues are critical for channel function. In the closed state, mutation of individual hydrophobic lipid lining residues to alanine, thus reducing the hydrophobicity, resulted in phenotypic changes that were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli Proteins
Share to Ion Channel Gating
Share to Ion Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lipid Bilayers

Share to Mechanotransduction, Cellular

Share to Membrane Potentials

Share to Patch-Clamp Techniques

Share to Pressure

Source

Open in PubMed Open full text

Identifiers

PMID: 25450806
DOI: 10.1016/j.bbamem.2014.10.022
PMCID: PMC4259861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mechanosensitive channel of small conductance (MscS) functions as a Jack-in-the box.PMID 25450806Read ↗

Defining the role of the tension sensor in the mechanosensitive channel of small conductance.Semantic proximity Read ↗

Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element.Semantic proximity Read ↗

Mutations in a Conserved Domain of E. coli MscS to the Most Conserved Superfamily Residue Leads to Kinetic Changes.Semantic proximity Read ↗

Generation and evaluation of a large mutational library from the Escherichia coli mechanosensitive channel of large conductance, MscL: implications for channel gating and evolutionary design.Semantic proximity Read ↗

The pathway and spatial scale for MscS inactivation.Semantic proximity Read ↗

The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution.Semantic proximity Read ↗

Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel.Semantic proximity Read ↗

Charged pore-lining residues are required for normal channel kinetics in the eukaryotic mechanosensitive ion channel MSL1.Semantic proximity Read ↗

State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation.Semantic proximity Read ↗

Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity.Semantic proximity Read ↗

Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states.Semantic proximity Read ↗

Negative and positive temperature dependence of potassium leak in MscS mutants: Implications for understanding thermosensitive channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.