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Article

One face of a transmembrane helix is crucial in mechanosensitive channel gating.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998

Ou X, Blount P, Hoffman R J, Kung C

Abstract excerpt

MscL is a mechanosensitive channel in bacteria that responds directly to membrane tension by opening a large conductance pore. To determine functionally important residues within this molecule, we have randomly mutagenized mscL, expressed the genes in living bacteria, and screened for gain-of-function mutants with hampered growth. Expression of these genes caused leakage of cytoplasmic solutes on little or no...

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Identifiers

PMID: 9736761
DOI: 10.1073/pnas.95.19.11471
PMCID: PMC21667

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Source receipt: pubmed, retrieved 7 Sept 2026.

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One face of a transmembrane helix is crucial in mechanosensitive channel gating.PMID 9736761Read ↗

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