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Article

Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity.

Biophysical journal - 1 Oct 1999

Yoshimura K, Batiza A, Schroeder M, Blount P, Kung C

Abstract excerpt

Mechanosensitive channel large (MscL) encodes the large conductance mechanosensitive channel of the Escherichia coli inner membrane that protects bacteria from lysis upon osmotic shock. To elucidate the molecular mechanism of MscL gating, we have comprehensively substituted Gly(22) with all other common amino acids. Gly(22) was highlighted in random mutagenesis screens of E. coli MscL (, Proc. Nat. Acad. Sci....

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Identifiers

PMID: 10512816
DOI: 10.1016/S0006-3495(99)77037-2
PMCID: PMC1300477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity.PMID 10512816Read ↗

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The role of the periplasmic loop residue glutamine 65 for MscL mechanosensitivity.Semantic proximity Read ↗

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