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Article

The role of the periplasmic loop residue glutamine 65 for MscL mechanosensitivity.

European biophysics journal : EBJ - 1 Jul 2005

Tsai I-Jung, Liu Zhen-Wei, Rayment John, Norman Christel, McKinley Allan, Martinac Boris

Abstract excerpt

The periplasmic loop of MscL, the mechanosensitive channel of large conductance, acts as a spring resisting the opening of the channel. Recently, a high-throughput functional screening of a range of MscL structural mutants indicated that the substitution of residue glutamine (Q) 65 with arginine (R) or leucine (L) leads to a wild-type (WT)-like and a loss-of-function (LOF) phenotype, respectively. We used...

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PMID: 15812636
DOI: 10.1007/s00249-005-0476-x

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SDSL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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