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Article

Loss-of-function mutations at the rim of the funnel of mechanosensitive channel MscL.

Biophysical journal - 1 Apr 2004

Yoshimura Kenjiro, Nomura Takeshi, Sokabe Masahiro

Abstract excerpt

MscL is a bacterial mechanosensitive channel that is activated directly by membrane stretch. Although the gene has been cloned and the crystal structure of the closed channel has been defined, how membrane tension causes conformational changes in MscL remains largely unknown. To identify the site where MscL senses membrane tension, we examined the function of the mutants generated by random and scanning...

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Identifiers

PMID: 15041651
DOI: 10.1016/S0006-3495(04)74270-8
PMCID: PMC1304062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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