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Article

The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Apr 2008

Taylor Warren D, Züchner Stephan, McQuoid Douglas R, Payne Martha E, MacFall James R, Steffens David C, Speer Marcy C, Krishnan K Ranga R

Abstract excerpt

OBJECTIVE: In animal models, brain-derived neurotrophic factor (BDNF) appears to protect against cerebral ischemia. The authors examined whether the BDNF Val66Met polymorphism, which affects BDNF distribution, was associated with greater volumes of hyperintense lesions as detected on magnetic resonance imaging in a cohort of depressed and nondepressed elders. DESIGN: Subjects completed cross-sectional...

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Source

Identifiers

PMID: 18263664
DOI: 10.1097/JGP.0b013e3181591c30

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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