Article
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Oct 2007
Taylor Warren D, Züchner Stephan, McQuoid Douglas R, Steffens David C, Speer Marcy C, Krishnan K Ranga R
Abstract excerpt
OBJECTIVE: The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with cognitive and neuroimaging changes. The authors examined the relationship between this polymorphism and depression in an elderly sample, hypothesizing that the Met66 allele would be associated with late-life depression. METHODS: A total of 245 elderly depressed white subjects and 94 elderly comparison white...
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