The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder.

doi:10.1016/j.pscychresns.2018.01.005

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Article

The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder.

Psychiatry research. Neuroimaging - 30 Mar 2018

Han Kyu-Man, Choi Sunyoung, Kim Aram, Kang June, Won Eunsoo, Tae Woo-Suk, Kim Yong-Ku, Lee Min-Soo, Ham Byung-Joo

Abstract excerpt

The serotonin-transporter-linked polymorphic region (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have been implicated in the pathophysiology of major depressive disorder (MDD). We aimed to investigate the effects of genetic variants of the 5-HTTLPR and BDNF Val66Met polymorphisms and their interactions with MDD on cortical volume and white matter integrity. Ninety-five patients...

Topics

Adult
Alleles
Anisotropy
Brain-Derived Neurotrophic Factor
Case-Control Studies
Depressive Disorder, Major
Diffusion Tensor Imaging
Emotions
Female
Genotype
Gray Matter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gyrus Cinguli

Humans

Male

Middle Aged

Organ Size

Polymorphism, Genetic

Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed

Identifiers

PMID: 29414128
DOI: 10.1016/j.pscychresns.2018.01.005

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder.PMID 29414128Read ↗

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