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Article

Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Jan 2011

Kanellopoulos Dora, Gunning Faith M, Morimoto Sarah S, Hoptman Matthew J, Murphy Christopher F, Kelly Robert E, Glatt Charles, Lim Kelvin O, Alexopoulos George S

Abstract excerpt

OBJECTIVES: structural abnormalities in the hippocampus have been implicated in the pathophysiology of major depressive disorder (MDD). The brain-derived neurotrophic factor (BDNF) val66met polymorphism may contribute to these abnormalities and therefore confer vulnerability to MDD. This study examined whether there is a relationship among BDNF genotype, hippocampal volumes, and MDD in older adults. METHODS:...

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Identifiers

PMID: 21218562
DOI: 10.1097/jgp.0b013e3181f61d62
PMCID: PMC3058412

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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