Article
Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.
European archives of psychiatry and clinical neuroscience - 1 Feb 2012
Gruber Oliver, Hasan Alkomiet, Scherk Harald, Wobrock Thomas, Schneider-Axmann Thomas, Ekawardhani Savira, Schmitt Andrea, Backens Martin, Reith Wolfgang, Meyer Jobst, Falkai Peter
Abstract excerpt
The brain-derived neurotrophic factor (BDNF) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus. The aim of the present study was to replicate and to extend prior findings of BDNF val66met genotype effects on hippocampal volume and N-acetyl aspartate (NAA)...
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