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Article

The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Apr 2010

Benjamin Sophiya, McQuoid Douglas R, Potter Guy G, Payne Martha E, MacFall James R, Steffens David C, Taylor Warren D

Abstract excerpt

OBJECTIVE: The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with geriatric depression. In studies of younger adults without depression, met allele carriers exhibit smaller hippocampal volumes and have poorer performance on neuropsychological tests. The...

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Identifiers

PMID: 20220593
DOI: 10.1097/JGP.0b013e3181cabd2b
PMCID: PMC2928477

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20220593-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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