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Article

Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.

Archives of general psychiatry - 1 Apr 2007

Frodl Thomas, Schüle Cornelius, Schmitt Gisela, Born Christine, Baghai Thomas, Zill Peter, Bottlender Ronald, Rupprecht Rainer, Bondy Brigitta, Reiser Maximilian, Möller Hans-Jürgen, Meisenzahl Eva M

Abstract excerpt

CONTEXT: Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression. OBJECTIVE: To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects. DESIGN: Cross-sectional comparison between patients and controls. SETTING: Inpatients with...

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Source

Identifiers

PMID: 17404118
DOI: 10.1001/archpsyc.64.4.410

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.PMID 17404118Read ↗

Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression.Semantic proximity Read ↗

The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.Semantic proximity Read ↗

BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis.Semantic proximity Read ↗

No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression.Semantic proximity Read ↗

Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis.Semantic proximity Read ↗

Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.Semantic proximity Read ↗

BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects.Semantic proximity Read ↗

The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression.Semantic proximity Read ↗

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Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder: A VBM analysis of brain MRI.Semantic proximity Read ↗

No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression.Semantic proximity Read ↗

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