The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.

doi:10.1523/JNEUROSCI.2680-04.2004

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Article

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Nov 2004

Pezawas Lukas, Verchinski Beth A, Mattay Venkata S, Callicott Joseph H, Kolachana Bhaskar S, Straub Richard E, Egan Michael F, Meyer-Lindenberg Andreas, Weinberger Daniel R

Abstract excerpt

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in...

Topics

Adolescent
Adult
Alleles
Amino Acid Substitution
Brain-Derived Neurotrophic Factor
Female
Genetic Variation
Hippocampus
Humans
Imaging, Three-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Learning

Magnetic Resonance Imaging

Male

Memory

Middle Aged

Neuronal Plasticity

Organ Size

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15537879
DOI: 10.1523/JNEUROSCI.2680-04.2004
PMCID: PMC6730170

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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