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Article

Role of cytotoxic T-lymphocyte-mediated immune selection in a dominant human leukocyte antigen-B8-restricted cytotoxic T-lymphocyte epitope in Nef.

Journal of acquired immune deficiency syndromes (1999) - 1 Jun 2008

Maurer Katja, Harrer Ellen G, Goldwich Andreas, Eismann Kathrin, Bergmann Silke, Schmitt-Haendle Matthias, Spriewald Bernd, Mueller Sandra M, Harrer Thomas

Abstract excerpt

OBJECTIVES: To study the role of cytotoxic T-lymphocyte (CTL) escape for disease progression in HIV-1 infection, we analyzed the CTL response to the dominant human leukocyte antigen (HLA)-B8-restricted CTL epitope FLKEKGGL (FL8) in HIV-1 Nef. METHODS: HIV-1 nef genes derived from 56 patients were analyzed by polymerase chain reaction (PCR)-based sequencing. T-cell responses against FL8 and mutated FL8 variants...

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Share to Acquired Immunodeficiency Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-B8 Antigen

Share to Immunodominant Epitopes

Share to nef Gene Products, Human Immunodeficiency Virus

Share to T-Lymphocytes, Cytotoxic

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Source

Identifiers

PMID: 18391752
DOI: 10.1097/QAI.0b013e31816fdc4a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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