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Article

Switching and emergence of CTL epitopes in HIV-1 infection.

Retrovirology - 21 May 2014

Han Chungyong, Kawana-Tachikawa Ai, Shimizu Akihisa, Zhu Dayong, Nakamura Hitomi, Adachi Eisuke, Kikuchi Tadashi, Koga Michiko, Koibuchi Tomohiko, Gao George F, Sato Yusuke, Yamagata Atsushi, Martin Eric, Fukai Shuya, Brumme Zabrina L, Iwamoto Aikichi

Abstract excerpt

BACKGROUND: Human Leukocyte Antigen (HLA) class I restricted Cytotoxic T Lymphocytes (CTLs) exert substantial evolutionary pressure on HIV-1, as evidenced by the reproducible selection of HLA-restricted immune escape mutations in the viral genome. An escape mutation from tyrosine to phenylalanine at the 135th amino acid (Y135F) of the HIV-1 nef gene is frequently observed in patients with HLA-A*24:02, an HLA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to HLA-A24 Antigen

Share to Human Immunodeficiency Virus Proteins

Share to nef Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 24886641
DOI: 10.1186/1742-4690-11-38
PMCID: PMC4036671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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