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Article

CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2005

Milicic Anita, Price David A, Zimbwa Peter, Booth Bruce L, Brown Helen L, Easterbrook Philippa J, Olsen Kara, Robinson Nicola, Gileadi Uzi, Sewell Andrew K, Cerundolo Vincenzo, Phillips Rodney E

Abstract excerpt

CTL play a critical role in the control of HIV and SIV. However, intrinsic genetic instability enables these immunodeficiency viruses to evade detection by CTL through mutation of targeted antigenic sites. These mutations can impair binding of viral epitopes to the presenting MHC class I molecule or disrupt TCR-mediated recognition. In certain regions of the virus, functional constraints are likely to limit the...

Read the complete abstract on PubMed

Topics

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Share to Antigen Presentation
Share to DNA, Intergenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Gene Products, nef

Share to HLA-B Antigens

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Proteasome Endopeptidase Complex

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 16177107
DOI: 10.4049/jimmunol.175.7.4618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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