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Article

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.

PLoS pathogens - 1 Jul 2007

Brumme Zabrina L, Brumme Chanson J, Heckerman David, Korber Bette T, Daniels Marcus, Carlson Jonathan, Kadie Carl, Bhattacharya Tanmoy, Chui Celia, Szinger James, Mo Theresa, Hogg Robert S, Montaner Julio S G, Frahm Nicole, Brander Christian, Walker Bruce D, Harrigan P Richard

Abstract excerpt

Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways. Population-based analyses of clinically derived HIV sequences may be used to identify immune escape mutations in viral genes; however, prior attempts to identify such mutations have been complicated by the...

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Share to CD4 Lymphocyte Count
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class I

Share to Human Immunodeficiency Virus Proteins

Share to Minor Histocompatibility Antigens

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Viral Regulatory and Accessory Proteins

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 17616974
DOI: 10.1371/journal.ppat.0030094
PMCID: PMC1904471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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