Article
Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection.
Biochemical and biophysical research communications - 17 Dec 2010
Mwimanzi Philip, Hasan Zafrul, Tokunaga Michiyo, Gatanaga Hiroyuki, Oka Shinichi, Ueno Takamasa
Abstract excerpt
HIV-1 Nef is a key factor for pathogenesis and is known to down-regulate functionally important molecules, including viral entry co-receptor CCR5 and CXCR4, from the surface of HIV-infected cells. Some of these Nef activities are mediated by the well-conserved proline-rich region of Nef, and this region is highly targeted by cytotoxic T lymphocytes (CTLs). In the present study, we asked whether Nef variants...
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