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Article

Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.

Journal of virology - 1 Mar 2018

Schouest Blake, Weiler Andrea M, Janaka Sanath Kumar, Myers Tereance A, Das Arpita, Wilder Sarah C, Furlott Jessica, Baddoo Melody, Flemington Erik K, Rakasz Eva G, Evans David T, Friedrich Thomas C, Maness Nicholas J

Abstract excerpt

Nef-specific CD8+ T lymphocytes (CD8TL) are linked to extraordinary control of primate lentiviral replication, but the mechanisms underlying their efficacy remain largely unknown. The immunodominant, Mamu-B*017:01+-restricted Nef195-203MW9 epitope in SIVmac239 partially overlaps a sorting motif important for interactions with host AP-2 proteins and, hence, downmodulation of several host proteins, including...

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Share to Epitopes, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to nef Gene Products, Human Immunodeficiency Virus

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Share to Simian Acquired Immunodeficiency Syndrome

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Share to Viral Regulatory and Accessory Proteins

Source

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Identifiers

PMID: 29237831
DOI: 10.1128/JVI.01822-17
PMCID: PMC5809740

Genes

SERINC5
SERINC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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