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Article

Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells.

Molecular and cellular biology - 1 Dec 2001

Luikenhuis S, Wutz A, Jaenisch R

Abstract excerpt

Expression of the Xist gene, a key player in mammalian X inactivation, has been proposed to be controlled by the antisense Tsix transcript. Targeted deletion of the Tsix promoter encompassing the DPXas34 locus leads to nonrandom inactivation of the mutant X, but it remains unresolved whether this...

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Share to Blotting, Southern
Share to Dosage Compensation, Genetic
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotides, Antisense

Share to RNA, Long Noncoding

Share to RNA, Untranslated

Share to Stem Cells

Share to X Chromosome

Source

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Identifiers

PMID: 11713286
DOI: 10.1128/MCB.21.24.8512-8520.2001
PMCID: PMC100014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11713286-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells.PMID 11713286Read ↗

Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.Semantic proximity Read ↗

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation.Semantic proximity Read ↗

Effect of TSIX disruption on XIST expression in male ES cells.Semantic proximity Read ↗

Regulation of imprinted X-chromosome inactivation in mice by <i>Tsix</i>Semantic proximity Read ↗

Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.Semantic proximity Read ↗

A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice.Semantic proximity Read ↗

Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation.Semantic proximity Read ↗

Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.Semantic proximity Read ↗

Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation.Semantic proximity Read ↗

Primary non-random X inactivation associated with disruption of Xist promoter regulation.Semantic proximity Read ↗

The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.Semantic proximity Read ↗

A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.Semantic proximity Read ↗

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