Article
Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.
Molecular and cellular biology - 1 Nov 2015
Ohhata Tatsuya, Matsumoto Mika, Leeb Martin, Shibata Shinwa, Sakai Satoshi, Kitagawa Kyoko, Niida Hiroyuki, Kitagawa Masatoshi, Wutz Anton
Abstract excerpt
One of the two X chromosomes in female mammals is inactivated by the noncoding Xist RNA. In mice, X chromosome inactivation (XCI) is regulated by the antisense RNA Tsix, which represses Xist on the active X chromosome. In the absence of Tsix, PRC2-mediated histone H3 lysine 27 trimethylation (H3K27me3) is established over the Xist promoter. Simultaneous disruption of Tsix and PRC2 leads to derepression of Xist...
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