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Article

A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice.

Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2001

Stavropoulos N, Lu N, Lee J T

Abstract excerpt

In female mammals, up-regulation of Xist triggers X-chromosome inactivation in cis. Up-regulation is inhibited by sequences 3' to Xist contained within the antisense locus, Tsix. Inhibition could depend on transcription of Tsix and/or on DNA elements therein. Here we test the role of Tsix transcription by augmenting the duration and strength of Tsix expression. We find that Tsix hypertranscription is sufficient...

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Share to DNA Primers
Share to Dosage Compensation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Elongation Factor 1

Share to Promoter Regions, Genetic

Share to RNA, Long Noncoding

Share to RNA, Untranslated

Share to Transcription, Genetic

Source

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Identifiers

PMID: 11481444
DOI: 10.1073/pnas.171243598
PMCID: PMC56944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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